… in diabetic nephropathy and elucidate its possible mechanism. … Inhibition of Src kinase
blocks high glucose-induced EGFR transactivation and collagen synthesis in mesangial cells …

… of CHOP in mouse mesangial cells significantly decreased … in mesangial cells is important
in treating diabetic nephropathy. … receptor inhibition slows progression of diabetic nephropathy …

… to the progression of diabetic kidney disease (DKD) remains … of Src kinase in diabetic db/db
mice 12 , STZ-DBA2/J mice 6 , … cytotoxicity assay with renal mesangial cells 10 . Moreover, a …

… high glucose induced collagen production in mesangial cells … for transactivation of EGFR
in mesangial cells to induce … activation of EGFR in diabetic kidney disease may mediate …

… These include effects on the proliferation of mesangial cells, apoptosis of renal tubular
cells, … in a mouse model of type 2 diabetes. We further observed that Src inhibitor treatment …

… role in the pathogenesis of diabetic nephropathy (DN), which … in high glucose-induced
GMCs, confirming the role of Src in … of Src kinase, this study revealed that both inhibition of Src …

… endothelial cells, mesangial cells, and tubular epithelial cells [12,… mediator of the EGFR,
important in glucose-induced pro-… EGFR transactivation has been demonstrated to be required …

… of c-Src on proliferation and fibrosis of mesangial cells as well as EMT of tubular epithelial
… in diabetic nephropathy [38, 39]. Importantly, inhibition of COX-2 via a specific inhibitor cel…

… phosphorylation and emphasize the inhibition of keap1-Nrf2 … , the formation of Keap1-Nrf2
complex and transactivation of ARE … 3, High glucose-induced mesangial cells could stimulate …

… and inducing fibrosis in diabetic kidney disease (DKD). The … EGFR in high glucose-induced
HRMCs and diabetic db/db … high glucose-induced human glomerular mesangial cells and …